CuBr for KA(2) reaction: en route to propargylic amines bearing a quaternary carbon center.
نویسندگان
چکیده
A highly efficient CuBr-catalyzed coupling of ketones, amines and alkynes (KA(2)) forming propargylic amines bearing a quaternary carbon center with the broadest scope so far has been developed.
منابع مشابه
An easily removable stereo-dictating group for enantioselective synthesis of propargylic amines.
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[reaction: see text] The reactions of propargylic alcohols, aliphatic primary amines, and CO2 were conducted in CuCl/[BMIm]BF4 system to produce the corresponding 5-methylene-1,3-oxazolidin-2-ones under relatively mild conditions. The products could be conveniently isolated by means of liquid-liquid extraction. The solvent ionic liquid as well as CuCl catalyst can be recovered and reused three ...
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 79 شماره
صفحات -
تاریخ انتشار 2013